I have used Bittrex for almost all of my transactions for quite a while now. I use Coinbase to buy crypto using a debit card and then transfer to Bittrex when I need to. I have a Ledger Nano wallet that I store almost everything on that I am holding right now. I have used Binance before but it isn't my favorite. I may go back and take a look now that they are offering transactions via debit card though! That is quite game changing and I am hoping that it works out for Binance!
Photo Retrieved from Bittrex website